The general research theme of CAVAREM is communication: after damage, during repair and regeneration, the microenvironment of tissues is continuously changing. Tissue cells start secrete trophic signaling factors that recruite inflammatory cells from the periphery. These circulating cells such as monocytes and other stem/progenitor cells are plastic and adopt a regenerative phenotype. CAVAREM seeks to dissect the communication network during tissue regeneration and investigates the underlying molecular and cellular pathways.